Clinical evaluation of verapamil in angina pectoris.

نویسندگان

  • G Sandler
  • G A Clayton
  • S G Thornicroft
چکیده

A controlled double-blind study of verapamil in 16 anginal patients used two dose levels-40 mg. t.d.s. and 120 mg. t.d.s.-and was compared with propranolol 100 mg. t.d.s. At the higher dosage verapamil produced a significant improvement in frequency of angina, trinitrin consumption, and exercise tolerance, and had a favourable and significant effect on the amount and duration of ischaemic S-T depression occurring in the electrocardiogram during exercise. In the lower dose verapamil produced significant subjective improvement but no objective benefit in the electrocardiogram. No significant differences were found between the favourable results with the higher dosage of verapamil and propranolol.The action of verapamil is not fully understood, but its favourable effects in angina may be due to a direct action on the myocardium, possibly with accompanying coronary vasodilatation.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison between Revascularization and Optimal Medical Therapy in Patients with Stable Angina Pectoris

Background and Purpose: Regarding usefulness of revascularization versus optimal medical therapy in patients with stable angina pectoris, data are challenging. The aim of this 12-month follow-up study was to compare the survival benefit associated with revascularization versus optimal medical therapy on the patients with stable angina pectoris. Materials and Methods: A prospective clinical s...

متن کامل

Comparison of the Effect of Lecture Training and Clinical Education on the Care of Patients with Angina Pectoris on Attitude of Nurses in Emergency Department of Military Hospitals of in Mashhad

Introduction: Nursing education has the task of preparing graduates with the ability to identify the needs of patients in a changing society and in the clinical setting, and provide the best possible care based on the best scientific evidence. Objective: The aim of this study was to compare the effect of lecture and clinical education on the care of patients with angina pectoris on attitude of ...

متن کامل

Effect of Opium Addiction on Aspirin Resistance in Stable Angina Pectoris

Background: The rate of cardiovascular diseases in developing countries is approximately 60% and it is still has an increasing trend. The clinical effectiveness of aspirin in preventing cardiovascular events has been well proven. Although aspirin is an effective and inexpensive drug, its consumption is not equally beneficial for all patients. Many factors can be affective on the efficacy of ant...

متن کامل

A double blind placebo controlled comparison of verapamil, atenolol, and their combination in patients with chronic stable angina pectoris.

The efficacy and effect on cardiac function of verapamil 120 mg three times a day and atenolol 100 mg once a day, singly and in combination, were evaluated in 15 patients with angina pectoris. While they were on the combination treatment four patients withdrew from the study. Episodes of angina pectoris and glyceryl trinitrate consumption were significantly reduced only on the combination. On t...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • British medical journal

دوره 3 5612  شماره 

صفحات  -

تاریخ انتشار 1968